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Fig. 1 | BMC Molecular and Cell Biology

Fig. 1

From: Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles

Fig. 1

Intercellular transfer of mitochondria-related vesicles. (a) Intercellular transfer of mitochondria-related vesicles between A11 and P29 cells. mtGFP-labeled A11 cells (A11-mtGFP) and MTDR-labeled P29 cells (P29-MTDR) were cocultured for 24 h and observed under a laser confocal microscope. Scale bars: 20 μm. (b) Intercellular transfer of mitochondria-related vesicles of A11 cells to P29 cells expressing EGFP. MTDR-labeled A11 cells (A11-MTDR) were cocultured with EGFP-P29 cells for 24 h. Arrows indicate EGFP-P29 cells harboring red-colored mitochondrial-related vesicles. Scale bars: 20 μm. (c) Time course of intercellular transfer of mitochondria-related vesicles. MTDR-labeled A11 cells (A11-MTDR) were cocultured with mtGFP-labeled P29 cells (P29-mtGFP) for 4 h and 24 h. The cells were observed under a laser confocal microscope. Scale bars: 20 μm

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BMC Molecular and Cell Biology

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