Figure 6From: A human polymorphism affects NEDD4L subcellular targeting by leading to two isoforms that contain or lack a C2 domainSummary schematic of the observed mobilization response of NEDD4L-C2(+) in response to a Ca2+ stimulus. NEDD4L-C2(+)-C943A that lacks ubiquitin ligase activity does not mobilize to the plasma membrane in step 4, and prevents β-ENaC transit to the plasma membrane in step 4.Back to article page