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Figure 4 | BMC Cell Biology

Figure 4

From: Aryl hydrocarbon receptor pathway activation enhances gastric cancer cell invasiveness likely through a c-Jun-dependent induction of matrix metalloproteinase-9

Figure 4

c-Jun mediates TCDD-induced MMP-9 expression and activity. (A) TCDD induces c-Jun mRNA expression in a dose-dependent manner. (B) TCDD induces c-Jun protein expression in a dose-dependent manner. (C) TCDD induces c-Jun mRNA expression in a time-dependent manner. (D) TCDD induces c-Jun protein expression in a time-dependent manner. (E) RSV reverses TCDD-induced c-Jun mRNA expression. (F) RSV reverses TCDD-induced c-Jun protein expression. (G) c-Jun siRNA silences c-Jun mRNA expression. (H) c-Jun siRNA silences c-Jun protein expression. (I) c-Jun siRNA inhibits TCDD-induced MMP-9 mRNA expression. (J) c-Jun siRNA inhibits TCDD-induced MMP-9 activity increase.

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BMC Molecular and Cell Biology

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