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Figure 10 | BMC Cell Biology

Figure 10

From: Stilbene glycosides are natural product inhibitors of FGF-2-induced angiogenesis

Figure 10

Compounds 1 and 2 inhibit in vivo angiogenesis in the CAM assay (see below for method). (I) methylcellulose alone showed no evidence of angiogenesis or inflammation, (II) FGF-2 induced a network of new blood vesselsradiating from the site of application (arrow), (III) and (IV) compounds 1 and 2 (10 μg) alone again showed no inflammatory or angiogenic response at the site of application. (V) and (VI) When compounds I and 2 (10 μg) were added together with FGF-2 there was complete inhibition of blood vessel formation. Representative photomicrographs are shown and the arrow indicates the point of application of the test compounds. Original magnification × 40.

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