Figure 1

Collagen lattice contraction is negatively regulated by β-catenin. A. Means and 95% confidence intervals for collagen lattice mean diameter as observed over seven days are given for fibroblasts from mice expressing the wild type, null, or stabilized β-catenin alleles, all treated with the adenovirus expressing cre recombinase in the absence of serum. There is a statistically significant difference between the stabilized and wild type cells for the time points with an asterisk below the data points. B. Representative photograph of the collagen lattices at day five. C. Western analysis for β-catenin showing successful recombination in the fibroblasts in the lattices. D. Means and 95% confidence intervals for collagen lattice mean diameter as observed over seven days are given for fibroblasts from mice expressing the wild type, null, or stabilized β-catenin alleles, all treated with the adenovirus expressing cre recombinase in the presence of serum. There is a statistically significant difference between either the stabilized or null cells and wild type cells at the time points with an asterisk either above or below the data points.