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Table 1 Dissociation constants for Tpr interaction with: CRM1, importin β or importin α.

From: Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr

Recombinant Protein

Kd apparent (nM)

CRM1

Too low to measure

CRM1+NES

176 ± 8 (3)

CRM1+NES+RanGTP

83 ± 5 (3)

Importin β

63 ± 5 (3)

Importin β I178D

Too low to measure

Importin α

21.5 ± 1.5 (3)

  1. Data represent the mean ± SD (number of repeats in parentheses) for the apparent dissociation constant
  2. Kd (see legend to Figs. 1 and 2).