Figure 1From: HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cellsSchematic diagrams for hypothesized HER receptor interaction patterns. These diagrams illustrate the EGFR-HER3 interaction patterns that have been reported in the literature. (A) EGFR and HER3 receptors interact directly, i.e., HER2 is not required; (B) HER2 is the explicit facilitator of a lateral interaction; and (C) EGFR and HER3 do not interact with each other but both of them independently interact with HER2. EGFR can also activate itself by forming homodimers.Back to article page