Skip to main content

Advertisement

Table 1 Effect of various substances on the cell surface expression of wild type (HA-WT) and mutant (HA-MM) HA-ABCA1 variants

From: Model system for the analysis of cell surface expression of human ABCA1

Drug Known effect ABCA1 cell surface expression
   HA-WT HA-MM
ALLN Calpain inhibitor (+ 60%) (+ 30%)
ApoA-I cholesterol acceptor (+ 30%) no effect
Atorvastatin cholesterol level lowering no effect no effect
Brefeldin A trans-Golgi transport inhibitor (- 60%) (- 40%)
Cycloheximide protein synthesis inhibitor (- 30%) (viability ) (- 30%) (viability )
Cyclosporin A immunosuppressor (+ 60%) (+ 60%)
Ezetimibe inhibitor of intestinal cholesterol absorption (- 20%) no effect
Glyburide ABCA1 inhibitor no effect no effect
Niacin cholesterol level lowering no effect no effect
Nifedipine Ca2+-channel blocker no effect no effect
Methyl-β-cyclodextrin cholesterol depletion no effect (viability ) no effect (viability )
Cholesterol-methyl-β-cyclodextrin cholesterol overloading no effect (viability ) no effect (viability )
Verapamil Ca2+-channel blocker no effect no effect