Skip to main content
Figure 8 | BMC Cell Biology

Figure 8

From: Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway

Figure 8

Model for reversal of EMT induced by TGF-β1. To re-express epithelial proteins such as E-cadherin, a TβRI kinase inhibitor is needed to decrease expression of mesenchymal genes (e.g., ZEB1 and ZEB2), while a Rho kinase inhibitor is required to stabilize the epithelial cortical actin. A p38 MAPK inhibitor may also be useful as this drug in conjunction with the TβRI kinase inhibitor can further EMT reversal by reducing stress fiber actin formation.

Back to article page