Figure 5
From: Monkey hybrid stem cells develop cellular features of Huntington's disease
Teratoma derived from TrES1 and expression of mutant htt in striatal graft of TrES1. Undifferentiated TrES1 and TrES1 derived NPCs were implanted into the striatum of SCID mice and recovered at six weeks for morphological and immunohistochemical analysis. (A) Hematoxylin and eosin staining of teratoma derived from undifferentiated TrES1. (B) Undifferentiated TrES1 (Left hemisphere) and TrES1 derived NPCs (Right hemisphere) were implanted into contralateral hemispheres of SCID mice. Immunohistochemical staining using mEM48 revealed the expression of mutant htt in both hemispheres (B-a and B-b). Areas surrounded by interrupted line indicated the locations of the cell graft.