TY - JOUR AU - Huang, See-Chang AU - Wu, Tzu-Chin AU - Yu, Hsiao-Chi AU - Chen, Mei-Ru AU - Liu, Chun-Min AU - Chiang, Wen-Sheng AU - Lin, Kurt M. PY - 2010 DA - 2010/03/10 TI - Mechanical strain modulates age-related changes in the proliferation and differentiation of mouse adipose-derived stromal cells JO - BMC Cell Biology SP - 18 VL - 11 IS - 1 AB - Previous studies on the effects of aging in human and mouse mesenchymal stem cells suggest that a decline in the number and differentiation potential of stem cells may contribute to aging and aging-related diseases. In this report, we used stromal cells isolated from adipose tissue (ADSCs) of young (8-10 weeks), adult (5 months), and old (21 months) mice to test the hypothesis that mechanical loading modifies aging-related changes in the self-renewal and osteogenic and adipogenic differentiation potential of these cells. SN - 1471-2121 UR - https://doi.org/10.1186/1471-2121-11-18 DO - 10.1186/1471-2121-11-18 ID - Huang2010 ER -