TY - JOUR AU - Pan, Pingxi AU - Fu, Hua AU - Zhang, Lingjun AU - Huang, He AU - Luo, Fengming AU - Wu, Wenchao AU - Guo, Yingqiang AU - Liu, Xiaojing PY - 2010 DA - 2010/05/26 TI - Angiotensin II upregulates the expression of placental growth factor in human vascular endothelial cells and smooth muscle cells JO - BMC Cell Biology SP - 36 VL - 11 IS - 1 AB - Atherosclerosis is now recognized as a chronic inflammatory disease. Angiotensin II (Ang II) is a critical factor in inflammatory responses, which promotes the pathogenesis of atherosclerosis. Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family cytokines and is associated with inflammatory progress of atherosclerosis. However, the potential link between PlGF and Ang II has not been investigated. In the current study, whether Ang II could regulate PlGF expression, and the effect of PlGF on cell proliferation, was investigated in human vascular endothelial cells (VECs) and smooth muscle cells (VSMCs). SN - 1471-2121 UR - https://doi.org/10.1186/1471-2121-11-36 DO - 10.1186/1471-2121-11-36 ID - Pan2010 ER -