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Figure 1 | BMC Cell Biology

Figure 1

From: Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation

Figure 1

IGF2 and IGFBP2 Expression is Up-regulated During Osteoblast Differentiation of hMSCs. Adult hMSCs were treated with or without dexamethasone (10-7M) to induce osteoblastic differentiation. Total RNA was collected from three different donors and used for microarray hybridization. Data were normalized and genes that were upregulated (fold change >2) in dexamethasone-treated compared to untreated MSCs were subselected (A). Analysis of gene network using Ingenuity Software indicated interactions between IGF2, IGFBP2 and ITGA5 (B).

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