TY - JOUR AU - Brocher, Jan AU - Vogel, Benjamin AU - Hock, Robert PY - 2010 DA - 2010/08/11 TI - HMGA1 down-regulation is crucial for chromatin composition and a gene expression profile permitting myogenic differentiation JO - BMC Cell Biology SP - 64 VL - 11 IS - 1 AB - High mobility group A (HMGA) proteins regulate gene transcription through architectural modulation of chromatin and the formation of multi-protein complexes on promoter/enhancer regions. Differential expression of HMGA variants has been found to be important for distinct differentiation processes and deregulated expression was linked to several disorders. Here we used mouse C2C12 myoblasts and C2C12 cells stably over-expressing HMGA1a-eGFP to study the impact of deregulated HMGA1 expression levels on cellular differentiation. SN - 1471-2121 UR - https://doi.org/10.1186/1471-2121-11-64 DO - 10.1186/1471-2121-11-64 ID - Brocher2010 ER -