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Figure 6 | BMC Cell Biology

Figure 6

From: F-Prostaglandin receptor regulates endothelial cell function via fibroblast growth factor-2

Figure 6

A schematic representation of PGF -FP receptor signalling which differentially regulates endothelial network formation and proliferation. PGF-FP receptor signalling in epithelial cells promotes the release of FGF2 into culture medium (conditioned medium). Conditioned medium treatment of HUVECs promotes the activation of ERK1/2 signalling via the FGF2-FGFR1. ERK1/2 activates divergent signalling pathways to endothelial proliferation and network formation. Endothelial proliferation is activated via mTOR. Endothelial network formation is activated via the induction of endothelial COX-2 enhancing the biosynthesis and release of PGF. Endothelial PGF subsequently acts on endothelial FP receptors to promote network formation (endothelial differentiation).

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