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Figure 2 | BMC Cell Biology

Figure 2

From: The role of hRev7, the accessory subunit of hPolζ, in translesion synthesis past DNA damage induced by benzo[a]pyrene diol epoxide (BPDE)

Figure 2

Reducing the level of hRev7 in human fibroblasts renders them more sensitive to the cytotoxic effect of BPDE, but does not affect their frequency of BPDE-induced mutations. The parental cells strain (open circles); cell strains with reduced hRev7, designated clones 2-2 and 2-6 (closed symbols); the vector control strain (open triangles); and a cell strain in which to level of hRev7 was reconstituted, designated 2-2 + R7 (open squares); were treated with BPDE and assayed for (A) cell survival or (B) the frequency of mutations induced in the HPRT gene. The lines represent the least squares regression for the data.

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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