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Figure 7 | BMC Cell Biology

Figure 7

From: 3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including "t-stumps"

Figure 7

3D nuclear staining of telomeres and DNA in U-HO1-PTPN1 RS-cells. A. Representative 2D Z-stack image no. 37 out of 80 shows a tri-nuclear RS-cell composed of two large and one small telomere-poor "ghost" satellite nucleus. Arrow identifies a mid-sized telomere also shown in B and C. B. 3D reconstruction in surface mode reveals relatively few (compared to cellular volume) mid-sized and short telomeres. Very short telomeres including t-stumps are rare. C. Combined 3D nuclear staining confirms 3D telomere dynamics identical to those observed in precursor H-cells (see Figure 4).

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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