Cell type | Parameter | H-HO1 | H-HO1-PTPN1 | p-value |
---|---|---|---|---|
Hodgkin | Total nuclear volume | 4121 ± 1350 μm3 | 3330 ± 844 μm3 | ns |
 | Telomeres/cell (n) (Total telomere volume) | 53.8 ± 28.0 | 56.2 ± 19.9 | ns |
 | Telomeres/1000 μm3 of nuclear volume (n) | 14.0 ± 8.4 | 17.2 ± 6.1 | ns |
 | Telomere aggregates/cell (n) | 6.0 ± 4.0 | 6.8 ± 4.2 | ns |
 | Cells with ≥ 20 telomere aggregates (%) | 2.9 | 2.8 | ns |
 | Very short telomeres (< 5000 units; %) | 21.2 | 18.3 | 0.0407 |
Reed-Sternberg | Total nuclear volume | 15301 ± 4641 μm3 | 14839 ± 6722 μm3 | ns |
 | Telomeres/cell (n) (Total telomere volume) | 123.0 ± 75.3 | 105.7 ± 62.7 | ns |
 | Telomeres/1000 μm3 of nuclear volume (n) | 13.7 ± 30.8 | 7.8 ± 4.0 | ns |
 | Telomere aggregates/cell (n) | 13.8 ± 11.7 | 12.9 ± 10.5 | ns |
 | Cells with ≥ 20 telomere aggregates (%) | 17.2 | 13.8 | ns |
 | Very short telomeres (< 5000 units; %) | 23.4 | 13.8 | < 0.0001 |