Skip to main content

Table 1 3D telomere characteristics of Hodgkin and Reed-Sternberg cells in U-HO1 and U-HO1-PTPN1

From: 3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including "t-stumps"

Cell type Parameter H-HO1 H-HO1-PTPN1 p-value
Hodgkin Total nuclear volume 4121 ± 1350 μm3 3330 ± 844 μm3 ns
  Telomeres/cell (n)
(Total telomere volume)
53.8 ± 28.0 56.2 ± 19.9 ns
  Telomeres/1000 μm3
of nuclear volume (n)
14.0 ± 8.4 17.2 ± 6.1 ns
  Telomere aggregates/cell (n) 6.0 ± 4.0 6.8 ± 4.2 ns
  Cells with ≥ 20 telomere
aggregates (%)
2.9 2.8 ns
  Very short telomeres
(< 5000 units; %)
21.2 18.3 0.0407
Reed-Sternberg Total nuclear volume 15301 ± 4641 μm3 14839 ± 6722 μm3 ns
  Telomeres/cell (n)
(Total telomere volume)
123.0 ± 75.3 105.7 ± 62.7 ns
  Telomeres/1000 μm3
of nuclear volume (n)
13.7 ± 30.8 7.8 ± 4.0 ns
  Telomere aggregates/cell (n) 13.8 ± 11.7 12.9 ± 10.5 ns
  Cells with ≥ 20 telomere
aggregates (%)
17.2 13.8 ns
  Very short telomeres
(< 5000 units; %)
23.4 13.8 < 0.0001
  1. ns: p > 0.05