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Table 1 Aurora-A and -B gene copy numbers in normal esophageal epithelial and esophageal cancer cell lines.

From: Occurrence of multipolar mitoses and association with Aurora-A/-B kinases and p53 mutations in aneuploid esophageal carcinoma cells

  

ESCC

BAC

 

EPC-hTERT

OE21

Kyse-410

OE33

OE19

Aurora-A

Aurora-A gene copies

2.0 ± 0.2

4.2 ± 0.5

9.1 ± 1.2

7.5 ± 0.9

3.9 ± 0.3

Centromere 20 signals

1.9 ± 0.3

4.1 ± 0.7

4.6 ± 0.9

7.2 ± 0.9

2.9 ± 0.4

Aurora-A/CEP20 ratio

1.1 ± 0.3

1.1 ± 0.3

2.0 ± 0.4

1.1 ± 0.1

1.4 ± 0.2

Aurora-B

Aurora-B gene copies

1.9 ± 0.4

3.0 ± 0.1

3.7 ± 0.8

2.9 ± 0.7

2.0 ± 0.2

Centromere 17 signals

2.0 ± 0.2

3.0 ± 0.1

3.8 ± 0.7

4.9 ± 0.9

3.9 ± 0.4

Aurora-B/CEP17 ratio

1.0 ± 0.2

1.0 ± 0.0

1.0 ± 0.1

0.6 ± 0.2

0.5 ± 0.1

  1. The table summarizes results of FISH analyses of control esophageal epithelial cells (EPC-hTERT) and all four esophageal cancer cell lines, with mean and ± standard deviation of gene specific (Aurora-A, Aurora-B) and centromere (CEP, chromosome enumeration probe) specific FISH signals as well as the amplification status (gene to centromere ratio: Aurora-A to CEP20; Aurora-B to CEP17).