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Table 1 Aurora-A and -B gene copy numbers in normal esophageal epithelial and esophageal cancer cell lines.

From: Occurrence of multipolar mitoses and association with Aurora-A/-B kinases and p53 mutations in aneuploid esophageal carcinoma cells

   ESCC BAC
  EPC-hTERT OE21 Kyse-410 OE33 OE19
Aurora-A
Aurora-A gene copies 2.0 ± 0.2 4.2 ± 0.5 9.1 ± 1.2 7.5 ± 0.9 3.9 ± 0.3
Centromere 20 signals 1.9 ± 0.3 4.1 ± 0.7 4.6 ± 0.9 7.2 ± 0.9 2.9 ± 0.4
Aurora-A/CEP20 ratio 1.1 ± 0.3 1.1 ± 0.3 2.0 ± 0.4 1.1 ± 0.1 1.4 ± 0.2
Aurora-B
Aurora-B gene copies 1.9 ± 0.4 3.0 ± 0.1 3.7 ± 0.8 2.9 ± 0.7 2.0 ± 0.2
Centromere 17 signals 2.0 ± 0.2 3.0 ± 0.1 3.8 ± 0.7 4.9 ± 0.9 3.9 ± 0.4
Aurora-B/CEP17 ratio 1.0 ± 0.2 1.0 ± 0.0 1.0 ± 0.1 0.6 ± 0.2 0.5 ± 0.1
  1. The table summarizes results of FISH analyses of control esophageal epithelial cells (EPC-hTERT) and all four esophageal cancer cell lines, with mean and ± standard deviation of gene specific (Aurora-A, Aurora-B) and centromere (CEP, chromosome enumeration probe) specific FISH signals as well as the amplification status (gene to centromere ratio: Aurora-A to CEP20; Aurora-B to CEP17).