|  | ESCC | BAC | ||
---|---|---|---|---|---|
 | EPC-hTERT | OE21 | Kyse-410 | OE33 | OE19 |
Aurora-A | |||||
Aurora A gene copies | 2.0 ± 0.2 | 4.2 ± 0.5 | 9.1 ± 1.2 | 7.5 ± 0.9 | 3.9 ± 0.3 |
Centromere 20 signals | 1.9 ± 0.3 | 4.1 ± 0.7 | 4.6 ± 0.9 | 7.2 ± 0.9 | 2.9 ± 0.4 |
Aurora-A mRNA | 0.4 ± 0.1 | 0.8 ± 0.1 | 2.7 ± 0.3 | 1.3 ± 0.3 | 1.6 ± 0.1 |
Aurora-A protein | ++ | + | +++ | +++ | + |
Aurora-A/phospho T288 | + | + | + | (+) | (+) |
Aurora-B | |||||
Aurora-B gene copies | 1.9 ± 0.4 | 3.0 ± 0.1 | 3.6 ± 0.8 | 2.9 ± 0.7 | 2.0 ± 0.2 |
Centromere 17 signals | 2.0 ± 0.2 | 3.0 ± 0.1 | 3.8 ± 0.7 | 4.9 ± 0.7 | 3.9 ± 0.4 |
Aurora A mRNA | 0.7 ± 0.0 | 1.2 ± 0.3 | 1.5 ± 0.5 | 0.7 ± 0.4 | 0.8 ± 0.2 |
Aurora-B protein | (+) | +++ | ++++ | ++ | + |
Aurora-B/phospho T232 | (+) | + | + | + | - |
p53 | |||||
Mutations | no mutation | c.269C>T, c.270delC, p.S90fs31X | c.1009C>T, p.R337C | c.404G>A, p.C135Y | c.928_930insA, p.N310fs26X |
p53 protein (kDa) | 53 | ~14 (truncated) | 53 | 53 | ~40 (truncated) |
p53 functionality | + | - | +/- | + | +/- |
Mitoses | |||||
Mitotic Index (%) | 1.0 ± 0.0% | 4.6 ± 1.2% | 2.2 ± 0.4% | 3.4 ± 2.2% | 3.2 ± 1.9% |
Multipolar mitoses (%) | 0.3 ± 0.6% | 7.7 ± 5.0% | 6.3 ± 2.0% | 13.8 ± 4.2% | 1.0 ± 1.0% |