Schemes illustrating the cell cycle alteration(s) observed in HeLa or NMuMG cells treated with different concentrations of etoposide or Cdk4 inhibitor. The cell-cycle processes that were visualized in this study are indicated by solid lines. Cell-cycle arrest (retardation) or nuclear mis-segregation is indicated by a vertical thick bar. C values denote DNA content as a multiple of the normal haploid genome. (A) Cell cycle arrest. (B) Nuclear mis-segregation. (C) Endoreplication cycle. Figures depicting the primary data are indicated in the square brackets. Nuclei are colored according to Fucci2 signals.