Figure 8

Expression of a CD8-cueball reporter construct increases GGA2 recruitment in HeLa cells. The cytoplasmic tails of CIMPR, LERP and cueball were expressed in a CD8 reporter system. Transient expression of CD8-CIMPR, CD8-LERP and CD8-cueball in HeLa cells resulted in the increase of GGA2 recruitment to membrane as shown by the increase in fluorescence intensity in the juxtanuclear region of the cell (arrowhead). The encircled cells highlight cells where there is no expression of CD8-constructs. Bar, 20 μm