TY - JOUR AU - Shiyu, Shu AU - Zhiyu, Ling AU - Mao, Ye AU - Lin, Bo AU - Lijia, Wang AU - Tianbao, Zhang AU - Jie, Chen AU - Tingyu, Li PY - 2011 DA - 2011/07/25 TI - Polydatin up-regulates clara cell secretory protein to suppress phospholipase A2 of lung induced by LPS in vivo and in vitro JO - BMC Cell Biology SP - 31 VL - 12 IS - 1 AB - Lung injury induced by lipopolysaccharide (LPS) remains one of the leading causes of morbidity and mortality in children. The damage to membrane phospholipids leads to the collapse of the bronchial alveolar epithelial barrier during acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Phospholipase A2 (PLA2), a key enzyme in the hydrolysis of membrane phospholipids, plays an important traumatic role in pulmonary inflammation, and Clara cell secretory protein (CCSP) is an endogenous inhibitor of PLA2. Our previous study showed that polydatin (PD), a monocrystalline extracted from a traditional Chinese medicinal herb (Polygonum cuspidatum Sieb, et Zucc), reduced PLA2 activity and sPLA2-IIA mRNA expression and mitigated LPS-induced lung injury. However, the potential mechanism for these effects has not been well defined. We have continued to investigate the effect of PD on LPS-induced expression of CCSP mRNA and protein in vivo and in vitro. SN - 1471-2121 UR - https://doi.org/10.1186/1471-2121-12-31 DO - 10.1186/1471-2121-12-31 ID - Shiyu2011 ER -