Figure 6
From: SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cells
Model depicting the role of SOX4 and plakoglobin in Wnt signaling regulation. When cells are stimulated with WNT3A, Wnt-responsive genes are upregulated by nuclear localization of β-catenin and transcriptional activation by the β-catenin-TCF/LEF and β-catenin-SOX4 complexes. Plakoglobin then shuttles into the nucleus and is exported out of the nucleus with SOX4. When nuclear export is inhibited by LMB, plakoglobin competes with β-catenin for SOX4 binding, destabilizes SOX4 binding to target promoters, and inhibits transcription of target genes.