TY - JOUR AU - Yu, Yanxun V. AU - Li, Zhihuan AU - Rizzo, Nicholas P. AU - Einstein, Jenifer AU - Welte, Michael A. PY - 2011 DA - 2011/02/24 TI - Targeting the motor regulator Klar to lipid droplets JO - BMC Cell Biology SP - 9 VL - 12 IS - 1 AB - In Drosophila, the transport regulator Klar displays tissue-specific localization: In photoreceptors, it is abundant on the nuclear envelope; in early embryos, it is absent from nuclei, but instead present on lipid droplets. Differential targeting of Klar appears to be due to isoform variation. Droplet targeting, in particular, has been suggested to occur via a variant C-terminal region, the LD domain. Although the LD domain is necessary and sufficient for droplet targeting in cultured cells, lack of specific reagents had made it previously impossible to analyze its role in vivo. SN - 1471-2121 UR - https://doi.org/10.1186/1471-2121-12-9 DO - 10.1186/1471-2121-12-9 ID - Yu2011 ER -