AA # | Observed change | Exon affected | Notes |
---|
633 | Ser to Thr | 7 | a, b |
1013 | Ser to Thr | 9 | a, b |
1210 | Ser to Ala | 11 | a, c |
1358 | Asp to Glu | 11 | a, b, c |
1366 | Ser to His | 11 | a, b, c |
1510 | Thr to Ser | 13 | a, b, c |
1577 | Ile to Asn | 14 | a, b, c |
Frame shift | See Fig. 1A | 15ext | Â |
1887 | Thr to Ser | 17 | a, b |
1909 | Ser to Ala | 17 | a, b |
- The protein coding exons of klarMW were sequenced, and the predicted protein sequence was compared to the wild-type Klar sequence available on FlyBase. The position of the sequence change is given relative to the protein sequence of the originally reported Klar α protein [24]. Exons numbering follows the convention established previously [22]. Notes indicate if a particular amino acid change is shared with other klar alleles.
- a present in KlarZ
- b present in a wild-type Klar α cDNA (GenBank AAD43129, as reported in [24])
- c present in various wild-type klar alleles (S. Jangi, Y. Guo, MAW, unpublished observations)