TY - JOUR AU - Li, Bin AU - Hu, Qingsong AU - Xu, Ranjie AU - Ren, Haigang AU - Fei, Erkang AU - Chen, Dong AU - Wang, Guanghui PY - 2012 DA - 2012/07/24 TI - Hax-1 is rapidly degraded by the proteasome dependent on its PEST sequence JO - BMC Cell Biology SP - 20 VL - 13 IS - 1 AB - HS-1-associated protein X-1 (Hax-1), is a multifunctional protein that has sequence homology to Bcl-2 family members. HAX-1 knockout animals reveal that it plays an essential protective role in the central nervous system against various stresses. Homozygous mutations in the HAX-1 gene are associated with autosomal recessive forms of severe congenital neutropenia along with neurological symptoms. The protein level of Hax-1 has been shown to be regulated by cellular protease cleavage or by transcriptional suppression upon stimulation. SN - 1471-2121 UR - https://doi.org/10.1186/1471-2121-13-20 DO - 10.1186/1471-2121-13-20 ID - Li2012 ER -