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Figure 2 | BMC Cell Biology

Figure 2

From: Co action of CFTR and AQP1 increases permeability of peritoneal epithelial cells on estrogen-induced ovarian hyper stimulation syndrome

Figure 2

Estrogen upregulates CFTR and AQP1 expression in peritoneal epithelial cells and induces OHSS in rats. Serum estrogen concentrations in OHSS were significantly different from control rats at both estrous and diestrous stages of the estrous cycle (A). ***P< 0.001 (n = 6, 6, and 6 for diestrus, estrus, and OHSS, respectively). Comparison of increased WT of rat 30 d after ovariectomy (control) and after treatment with progesterone or estrogen for 5 d (n = 5/group), showing significantly increased WT by estrogen (B). ***P< 0.001 (compared with the control). Western blot results showed downregulation of CFTR and AQP1 expression by progesterone and upregulation expression by estrogen in peritoneal epithelial cells of ovariectomized rats. The Pixel Value for CFTR: ovariectomy 260546, Progesterone 202730, Estrogen 885290, Estrogen+Progesterone 363422; The Pixel Value for AQP1: ovariectomy 186484, Progesterone 101092, Estrogen 877020, Estrogen+Progesterone 160054; The Pixel Value for β-Actin: ovariectomy 708508, Progesterone 707448, Estrogen 707982, Estrogen+Progesterone 709654 (C).

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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