Knockdown of ceMTM3 induces increased lysosomal activity. Day 5 adult worms were treated with acridine orange on NGM plates. Data represent fluorescence and DIC images of the same worm sections. Arrows indicate lysosomes which are abundant in ceMTM3 RNAi-treated worms. Note that muscle fibers are visible in DIC images, indicating increased numbers of lysosomes are present in muscle cells.