TY - JOUR AU - Somesh, Baggavalli P. AU - Verma, Mahesh Kumar AU - Sadasivuni, Manoj Kumar AU - Mammen-Oommen, Anup AU - Biswas, Sanghamitra AU - Shilpa, Pavagada C. AU - Reddy, Ashok Kumar AU - Yateesh, Aggunda N. AU - Pallavi, Puttrevana M. AU - Nethra, Siddaraju AU - Smitha, Rachapalli AU - Neelima, Korrapati AU - Narayanan, Usha AU - Jagannath, Madanahalli R. PY - 2013 DA - 2013/07/01 TI - Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity JO - BMC Cell Biology SP - 31 VL - 14 IS - 1 AB - In the progression towards diabetes, glucolipotoxicity is one of the main causes of pancreatic beta cell pathology. The aim of this study was to examine the in vitro effects of chronic glucolipotoxic conditions on cellular responses in pancreatic islets, including glucose and fat metabolism, Calcium mobilization, insulin secretion and insulin content. SN - 1471-2121 UR - https://doi.org/10.1186/1471-2121-14-31 DO - 10.1186/1471-2121-14-31 ID - Somesh2013 ER -