TY - JOUR AU - Cheng, Yue AU - Cheung, Arthur Kwok Leung AU - Ko, Josephine Mun Yee AU - Phoon, Yee Peng AU - Chiu, Pui Man AU - Lo, Paulisally Hau Yi AU - Waterman, Marian L. AU - Lung, Maria Li PY - 2013 DA - 2013/09/27 TI - Physiological β-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma JO - BMC Cell Biology SP - 44 VL - 14 IS - 1 AB - A few reports suggested that low levels of Wnt signaling might drive cell reprogramming, but these studies could not establish a clear relationship between Wnt signaling and self-renewal networks. There are ongoing debates as to whether and how the Wnt/β-catenin signaling is involved in the control of pluripotency gene networks. Additionally, whether physiological β-catenin signaling generates stem-like cells through interactions with other pathways is as yet unclear. The nasopharyngeal carcinoma HONE1 cells have low expression of β-catenin and wild-type expression of p53, which provided a possibility to study regulatory mechanism of stemness networks induced by physiological levels of Wnt signaling in these cells. SN - 1471-2121 UR - https://doi.org/10.1186/1471-2121-14-44 DO - 10.1186/1471-2121-14-44 ID - Cheng2013 ER -