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Table 2 Protein annotation for biological processes of upregulated proteins

From: New insights in osteogenic differentiation revealed by mass spectrometric assessment of phosphorylated substrates in murine skin mesenchymal cells

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GO term

#Seq

Score

GO term

#Seq

Score

GO term

#Seq

Score

GO term

#Seq

Score

Signaling

14

4,21

Signaling

31

8,92

Signaling

40

13,3

Developmental process

47

15

Cellular response to stimulus

19

5,67

Anatomical structure development

22

9,48

Multicellular organismal development

48

12,78

Signaling

17

4,13

Anatomical structure morphogenesis

13

4,21

Multicellular organismal development

8

2,39

Anatomical structure development

46

13,06

Anatomical structure development

41

12,3

Cell differentiation

18

5,95

Cell differentiation

6

2,48

Cell-cell signaling

9

2,96

Multicellular organismal development

43

8,57

Regulation of signaling

6

1,08

Cell surface receptor linked signaling pathway

3

2,6

Cell activation

7

3,18

Cell differentiation

20

9,36

Cell morphogenesis involved in differentiation

7

2,06

Cell morphogenesis involved in differentiation

30

5,77

System development

40

10,12

Cell surface receptor linked signaling pathway

9

3,63

Organ development

21

8

G-protein coupled receptor protein signaling pathway

4

3,2

Cell differentiation

33

15,09

Embryo development

7

3,14

Regulation of cell differentiation

6

1,12

Signal transduction

8

2,14

Cytoskeleton organization

26

9,55

System development

36

8,95

Signal transduction

11

5,73

Epithelial cell differentiation

13

6,01

Regulation of signaling

20

6,75

Cell development

15

5,97

   

Phosphorylation

14

4,67

Cell surface receptor linked signaling pathway

18

7,95

Cell morphogenesis involved in differentiation

9

2,47

   

Transmembrane receptor protein tyrosine kinase signaling pathway

4

2,56

Signal transduction

37

18,99

Organ development

26

10,7

      

Organ development

26

11,08

Regulation of signal transduction

6

2,1

      

Cell morphogenesis involved in differentiation

13

3,15

Signal transduction

17

6,54

      

Enzyme linked receptor protein signaling pathway

9

3,8

Epithelial cell differentiation

2

2

      

Intracellular protein kinase cascade

7

3,34

Regulation of gene expression

14

4,89

      

G-protein coupled receptor protein signaling pathway

6

4,77

Transmembrane receptor protein tyrosine kinase signaling pathway

5

2,92

      

Small GTPase mediated signal transduction

5

2,01

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

3

3

      

Second-messenger-mediated signaling

3

1,22

Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

4

4

      

Wnt receptor signaling pathway

3

1,08

Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

4

4

      

Phosphorylation

17

8,1

Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

4

4,8

      

Positive regulation of signal transduction

9

5,2

   
      

Transmembrane receptor protein tyrosine kinase signaling pathway

9

6,33

   
      

MAPKKK cascade

5

4

   
      

Negative regulation of cell proliferation

5

4,6

   
      

Positive regulation of intracellular protein kinase cascade

5

3

   
      

Negative regulation of cell cycle

4

1,84

   
      

Post-translational protein modification

4

4

   
      

Ras protein signal transduction

4

1,68

   
      

Regulation of Wnt receptor signaling pathway

3

1,56

   
  1. Consistently upregulated proteins were input in Blast2go software for mapping and annotation of gene ontologies. Biological processes over-represented were selected and classified according to level. Top: low levels; bottom.