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Figure 5 | BMC Cell Biology

Figure 5

From: THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier

Figure 5

Depletion of the THOC5 gene causes severe pathological alteration in the gastrointestinal tract. Rosa26-Cre ERT2 and Rosa26-Cre ERT2:THOC5 (flox/flox) mice were treated with (+) or without (−) tamoxifen and jejunum (A-E), caecum (E), and colon (E) were fixed in formalin. Paraffin sections were stained by hematoxylin and eosin (HE) (A) or were supplied for immunohistochemical staining using THOC5 (B, E), Ki67 (C), and cleaved caspase 3 (Cl. Caspase 3) (D) specific antibodies as indicated. Bars represent 400 μm (HE) or 20 μm (immunohistochemical staining).

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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