Depletion of the THOC5 gene causes severe pathological alteration in the gastrointestinal tract. Rosa26-Cre ERT2 and Rosa26-Cre ERT2:THOC5 (flox/flox) mice were treated with (+) or without (−) tamoxifen and jejunum (A-E), caecum (E), and colon (E) were fixed in formalin. Paraffin sections were stained by hematoxylin and eosin (HE) (A) or were supplied for immunohistochemical staining using THOC5 (B, E), Ki67 (C), and cleaved caspase 3 (Cl. Caspase 3) (D) specific antibodies as indicated. Bars represent 400 μm (HE) or 20 μm (immunohistochemical staining).