Table 1 p- values for PANTHER analysis of pathways, molecular function and biological processes of transcripts bound in (A) hNP1 and (B) hNP1 cells differentiated to neurons over 6Â days (6dN)
From: BORIS/CTCFL is an RNA-binding protein that associates with polysomes
A. | ||
|---|---|---|
| Â | BORIS bound transcripts in hNP1 | p- value |
Pathway | Â | Â |
WNT signaling pathway | 33 | 0.00000258 |
Cadherin signaling pathway | 23 | 0.00000012 |
Huntington disease | 13 | 0.0252 |
Molecular function | Â | Â |
binding | 401 | 6.54E-18 |
nucleic acid binding | 253 | 1.49E-14 |
DNA binding | 164 | 2.39E-10 |
transcription factor activity | 143 | 3.48E-09 |
transcription regulator activity | 143 | 3.48E-09 |
RNA binding | 48 | 7.86E-07 |
RNA splicing factor activity, transesterification mechanism | 27 | 3.56E-05 |
helicase activity | 19 | 5.85E-05 |
RNA helicase activity | 13 | 1.73E-04 |
catalytic activity | 263 | 9.25E-04 |
Biological process | Â | Â |
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 252 | 8.72E-15 |
metabolic process | 422 | 3.19E-08 |
primary metabolic process | 407 | 5.66E-08 |
cellular component organization | 94 | 1.45E-05 |
protein transport | 103 | 2.76E-05 |
intracellular protein transport | 103 | 2.76E-05 |
organelle organization | 29 | 1.74E-04 |
establishment or maintenance of chromatin architecture | 27 | 2.42E-04 |
nervous system development | 78 | 3.60E-04 |
vesicle-mediated transport | 72 | 5.89E-04 |
B. | Â | Â |
| Â | BORIS bound transcripts in 6dN | p -value |
Pathway | Â | Â |
WNT signaling pathway | 19 | 0.0325 |
Angiogenesis | 16 | 0.00275 |
Inflammation mediated by chemokine and cytokine signaling pathway | 15 | 0.115 |
Alzheimer disease-presenilin pathway | 12 | 0.00257 |
TGF-beta signaling pathway | 10 | 0.049 |
Molecular function | Â | Â |
binding | 315 | 1.05E-06 |
nucleic acid binding | 191 | 1.76E-05 |
catalytic activity | 245 | 1.26E-04 |
protein binding | 156 | 1.39E-04 |
transferase activity, transferring glycosyl groups | 22 | 1.67E-04 |
ubiquitin-protein ligase activity | 29 | 2.83E-04 |
DNA binding | 122 | 3.80E-04 |
transferase activity | 85 | 6.67E-04 |
ligase activity | 38 | 2.03E-03 |
RNA splicing factor activity, transesterification mechanism | 20 | 3.28E-03 |
Biological process | Â | Â |
cell cycle | 114 | 7.90E-08 |
primary metabolic process | 368 | 8.83E-08 |
metabolic process | 376 | 4.35E-07 |
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 196 | 1.26E-06 |
protein transport | 94 | 3.18E-05 |
intracellular protein transport | 94 | 3.18E-05 |
protein metabolic process | 162 | 5.45E-05 |
cellular process | 284 | 5.66E-05 |
transport | 145 | 7.51E-05 |
mitosis | 41 | 6.49E-04 |