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Table 2 Summary of cytotoxicity data of potential transporter inducers (24-96 hours of exposure)

From: Primary porcine proximal tubular cells as an alternative to human primary renal cells in vitro: an initial characterization

Substances (Abbrev.)

Solvent

Concentration range tested (n concentrations)

Significant effects

bromosulphophthalein (BSP)

H2O

10 nM-20 μM (7)

no

p-aminohippuric acid (PAH)

H2O

10 nM-20 μM (7)

no

taurocholic acid (TCA)

EtOH

10 nM-20 μM (7)

no

triiodothyronine (T3)

PBS

100 pM-6.2 μM (7)

no

dehydroepi-androsteron sulfate (DHEAS)

H2O

10 nM-20 μM (7)

no

testosterone (TEST)

EtOH

10 nM-4 μM (7)

no

dexamethasone (DEX)

50% EtOH

100 pM-10 μM (6)

no

  1. Data represent n = 3-4 independent experiments, conducted in duplicate. One-way ANOVA with Dunnett’s multiple comparison test (P < 0.05).