Figure 4

CD44⁺CD117⁺CSCs with multidrug resistance property in 3D culture. A shows the cellular growth inhibitory rates of anticancer drugs 5FU, CDDP, CBP, and DXT to the CD44⁺CD117⁺CSCs and the SKOV-3 cells in 3D culture and the 2D one, respectively. IC₅₀ concentrations of 5FU, CDDP, CBP and DXT were 17.18 μg/mL, 18.6 μg/mL, 20.5 μg/mL, and 72 μg/mL, respectively, in the CD44⁺CD117⁺CSCs group. B likewise indicates the inhibitory rates of 5FU, CDDP, CBP, and DXT to CD44⁺CD117⁺CSCs and SKOV-3 cells in IC₅₀ concentration, two-folds IC₅₀ concentration and ten-folds IC₅₀ concentration, respectively. * P < 0.05 and ^#P > 0.05.