C57BL/6 mouse corneas 7 days after implantation with pellets (asterisks) containing different reagents. A, phosphate buffered saline (PBS); B, 160 ng VEGF; C, 160 ng VEGF and 1 μg H-RN; D, 160 ng VEGF and 5 μg H-RN. VEGF pellets induced a strong neovascular response, originating from the corneal limbal vessels and reaching the pellet. Pellets containing VEGF and 1 μg H-RN also induced a neovascular response, but this was less intense. Pellets containing VEGF and 5 μg H-RN resulted in a mild vascular response compared to VEGF group.