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Figure 5 | BMC Cell Biology

Figure 5

From: FAP-α (Fibroblast activation protein-α) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway

Figure 5

Effect of small inhibitors on the impaired motility ability of MCF7 breast cancer cells. A panel of small inhibitors linked to motility was screened, with only the FAK inhibitor having a substantial effect. ECIS was used to assess the effect of these inhibitors on cell migration/motility. Again, we looked at the two phases of the experiment, attachment and migration. (A and B) There was little difference in attachment upon addition of the small inhibitors to MCF7exp cells (n-16). (C and D) The FAK inhibitor was seen to partially restore the inhibitory effect of FAP-α on the motility of MCF7exp cells (n = 16).

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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