Figure 2

Cartoon illustration of different possibilities of chromosome 11 orientation pairs in the nucleus. The representative chromosome is composed of four differently colored segments; green segments represent telomeric ends, magenta segments centromeric ends, proximal and distal (not measured) interstitial segments are shown in cyan blue and red, respectively. The nucleus is illustrated in blue; the black circles divide the nucleus into central, intermediate and peripheral regions (PP = both homologs parallel to the nuclear periphery, PC/PT = one homolog is located in parallel to the periphery, while the other is oriented with its centromeric (red)/telomeric (green) end towards the nuclear periphery, TT = both homologs point with their telomeric (green) ends towards the periphery, CT = one homolog with its centromeric (red) end and the other homolog with its telomeric (green) end pointing towards the nuclear periphery, CC = both homologs point with their centromeric (red) ends towards the nuclear periphery, ). PP, PC and PT in the first row of Figure 2 are observed most frequently.