TY - JOUR AU - Wimuttisuk, Wananit AU - West, Mark AU - Davidge, Brittney AU - Yu, Kebing AU - Salomon, Arthur AU - Singer, Jeffrey D. PY - 2014 DA - 2014/07/10 TI - Novel Cul3 binding proteins function to remodel E3 ligase complexes JO - BMC Cell Biology SP - 28 VL - 15 IS - 1 AB - Cullins belong to a family of scaffold proteins that assemble multi-subunit ubiquitin ligase complexes to recruit protein substrates for ubiquitination via unique sets of substrate adaptor, such as Skp1 or Elongin B, and a substrate-binding protein with a conserved protein-protein interacting domain, such as l eucine-r ich r epeats (LRR), a WD40 domain, or a zinc-finger domain. In the case of the Cullin3 (Cul3), it forms a B TB-C ul3-R bx1 (BCR) ubiquitin ligase complex where it is believed that a BTB domain-containing protein performs dual functions where it serves as both the substrate adaptor and the substrate recognition protein. SN - 1471-2121 UR - https://doi.org/10.1186/1471-2121-15-28 DO - 10.1186/1471-2121-15-28 ID - Wimuttisuk2014 ER -