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Figure 7 | BMC Cell Biology

Figure 7

From: Mitochondrial localization of the OAS1 p46 isoform associated with a common single nucleotide polymorphism

Figure 7

Model of the 2-5A system. OAS and RNase L, two of the enzymes constituting the 2-5A system, localizes to the cytoplasm as well as to the mitochondria rendering a full 2-5A system present in both the cytoplasm and the mitochondria (light green/ivory). Individuals carrying the G allele of polymorphism rs10774671 generally have a higher amount of OAS protein in the mitochondria represented by the OAS1 p46 isoform (red arrows), whereas individuals harbouring the A allele in general have higher levels of OAS in the cytoplasm (black arrows). The 2-5As synthesized in the cytoplasm, activate cytosolic RNaseL and are themselves regulated by an unknown 5′-phosphatase. The resulting products, 2-5A core molecules are transported to the mitochondrial matrix and degraded by a 2′ phosphodiesterase (known as PDE12), or alternatively, degraded by an unknown 2′phosphodiesterase located in the cytosol. 2-5As are also synthesized in the mitochondria leading to activation of mitochondrial RNaseL. The 2-5As are here prone to direct degradation by PDE12, or alternatively trimmed by a phosphatase before degradation by PDE12. The cell is not drawn to scale.

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