Figure 1From: Rapamycin promoted thrombosis and platelet adhesion to endothelial cells by inducing membrane remodelingRapamycin promoted thrombosis in rats. (A) The diagram of the DVT rat model illustrated that the iliac vein which was tied at site A was injected with rapamycin or DMSO and then tied tightly at the sites of a and b. (B) The ratio of thrombosis in rapamycin group (80%) is far more than that in DMSO (20%) group. n = 10 in each group. (C) HE staining exhibited thrombosis in the venous lumen at the time of the 40th minute. Enlarged squares indicate the platelet-derived clot appeared in the thrombus. (D) Transmission electron microscope analysis exhibited microvilli-like structure on endothelial of rapamycin treated rats compared with the smooth endothelial surface in the DMSO treated rats (TEM × 10, 000).Back to article page