Figure 4
The membrane remodeling is essential for platelet-endothelial adhesion. HUVECs were treated with the indicated reagents. Cells were fixed and detected by immunofluorescence with an anti-β-actin antibody. (A) The dorsal ruffle was indicated by arrows. (B) The ratio of cells with dorsal ruffle to total cells was evaluated. The data showed that Cytochalasin B attenuated platelets-endothelial adhesion which was induced by rapamycin. Means ± SD are given and were obtained from 3 independent experiments.