Figure 3

Transmission electron micrographs of Ocl from control (Fig. 3A) and from estradiol-treated (Fig. 3B and 3C) mice. Note the normal, extensive ruffled border present on the margin of an Ocl from a control femur (Fig. 3A). In estradiol treated animals, Ocl show either very small portions of the cell perimeter involved with ruffled border formation and the remainder of the cell surface reveals a smooth profile (Fig. 3B) or no ruffled border formation (Fig. 3C). (Fig. 3A, X 3,290; 3B, X 1,310; 3C, X 4,230)