Diagrammatic representation of the human LTBP-3 protein. Note that for the amino acid sequence derived for the monkey LTBP-3 (Mk LTBP-3), the monkey, mouse and human LTBP-3 proteins have the same structural features. Symbols represent structural features of the protein: cysteine-rich regions, patterned octagons; proline/glycine rich region, solid line; fibrillin motif, open rectangle; calcium-binding type II EGF-like modules, open octagons; cysteine-rich TGF-bp repeats, dotted punched tape symbol; TGF-bp-like repeat, wavy lined punched tape symbol. The numbers 1-5 represent different domains of the protein. The construct insert of pGAD424/LTBP-3 EGF #1-8, containing the region of Mk LTBP-3 that interacts with the extracellular domain of proHB-EGF (DTREx), is shown as a forward slashed box.