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Figure 3 | BMC Cell Biology

Figure 3

From: Latent transforming growth factor β-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor

Figure 3

Diagrammatic representation of the human fibulin-1C protein (modified after Argraves et al. [33]). Note that for the derived amino acid sequence obtained for the monkey fibulin-1C protein, the human and monkey fibulin-1C proteins have identical structural features. Symbols represent the following structural features: anaphylatoxin type I repeats, diamonds; potential N-glycosylation site, small circle; EGF-adjoining sequence, dotted oval; calcium-binding type II EGF-like modules, open octagons; potential Asn/Asp hydroxylation site, triangles, potential o-glycosylation site, inverted triangles; fibulin-type module, large hexagon. The construct insert of pGAD424/Fib-1C EGF #1–5 is represented by a dotted box. The construct insert of pGAD424/Fib-1C EGF #5-COOH, containing a region of fibulin-1C that interacts with the extracellular domain of monkey proHB-EGF (DTREx), is represented by a forward slashed box.

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