Figure 7
From: Astroglial expression of the P-glycoprotein is controlled by intracellular CNTF
Effect of cytokines on CNTF-intracellular content astrocytes. Among all the molecules tested, only LIF and CT-1 induced a CNTF-modulation in long term astrocyte culture. Addition of rhLIF during 24 h elicited a significant increase of P-gp expression both at 10 and 30 ng/ml (+56.12 % ± 25, factorial ANOVA significant at 95%, t-test p < 0.05* and +33.8 % ± 8, factorial ANOVA significant at 95%, t-test p < 0.01** respectively). The same pattern of regulation was observed with CT-1 (+44.5 % ± 12, factorial ANOVA significant at 95%, t-test p < 0.01** and +15.1 % ± 5, factorial ANOVA significant at 95%, t-test p < 0.05*).