TY - JOUR AU - Chen, Chii-Shiarng PY - 2002 DA - 2002/08/06 TI - Phorbol ester induces elevated oxidative activity and alkalization in a subset of lysosomes JO - BMC Cell Biology SP - 21 VL - 3 IS - 1 AB - Lysosomes are acidic organelles that play multiple roles in various cellular oxidative activities such as the oxidative burst during cytotoxic killing. It remains to be determined how lysosomal lumen oxidative activity and pH interact and are regulated. Here, I report the use of fluorescent probes to measure oxidative activity and pH of lysosomes in live macrophages upon treatment with the tumor promotor phorbol 12-myristate 13-acetate (PMA), and provide novel insight regarding the regulation of lysosomal oxidative activity and pH. SN - 1471-2121 UR - https://doi.org/10.1186/1471-2121-3-21 DO - 10.1186/1471-2121-3-21 ID - Chen2002 ER -