TY - JOUR AU - Lu, Lifang AU - Schulz, Holger AU - Wolf, Dieter A. PY - 2002 DA - 2002/08/20 TI - The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells JO - BMC Cell Biology SP - 22 VL - 3 IS - 1 AB - The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. The mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased proteolysis mediated by the SCFSKP2 ubiquitin ligase complex. Here we used the human prostate cancer cell line LNCaP, which undergoes G1 cell cycle arrest in response to androgen, to examine the role of the SKP2 F-box protein in p27 regulation in prostate cancer. SN - 1471-2121 UR - https://doi.org/10.1186/1471-2121-3-22 DO - 10.1186/1471-2121-3-22 ID - Lu2002 ER -