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Table 1 Mutations affecting the GTP/GDP cycle of Rab27a

From: Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models

Rab27a mutation

expected biochemical properties

expected effect

T23N

preferential binding of GDP

dominant-negative

Q78L

reduced GTPase activity

constitutively-active

N133I

low affinity for GDP/GTP

dominant-negative